| Date | Location | Result | |
| 03/05/22 | Homewood, AL | Union University 59, Delta State 51 | Box score |
| 03/01/22 | Pensacola, FL | Delta State 63, West Florida 51 | Box score |
| 02/26/22 | Huntsville, AL | Delta State 61, Alabama Huntsville 55 | Box score |
| 2/24/22 | Livingston, AL | Delta State 71, West Alabama 68 | Box score |
| 02/19/22 | Cleveland, MS | Montevallo 70, Delta State 69 | Box score |
| 02/17/22 | Cleveland, MS | Delta State 60, Auburn Montgomery 52 | Box score |
| 02/12/22 | Memphis, TN | Christian Brothers 71, Delta State 69 | Box score |
| 02/10/22 | Jackson, TN | Union University 60, Delta State 47 | Box score |
| 02/07/22 | Cleveland, MS | Delta State 78, Mississippi Col. 51 | Box score |
| 02/05/22 | Clinton, MS | Mississippi Col. 59, Delta State 50 | Box score |
| 01/26/22 | Cleveland, MS | Delta State 76, West Georgia 65 | Box score |
| 01/22/22 | Cleveland, MS | Lee 69, Delta State 67 | Box score |
| 01/20/22 | Cleveland, MS | Delta State 77, Shorter University 69 | Box score |
| 01/15/22 | Pensacola, FL | West Florida 56, Delta State 52 | Box score |
| 01/13/22 | Valdosta, GA | Valdosta State 47, Delta State 35 | Box score |
| 01/05/22 | Carrollton, GA | West Georgia 74, Delta State 60 | Box score |
| 12/20/21 | Cleveland, MS | Union University 77, Delta State 63 | Box score |
| 12/18/21 | Cleveland, MS | Delta State 82, Christian Brothers 67 | Box score |
| 12/14/21 | Montevallo, AL | Delta State 77, Montevallo 68 | Box score |
| 12/12/21 | Montgomery, AL | Delta State 57, Auburn Montgomery 51 | Box score |
| 12/04/21 | Cleveland, MS | Delta State 78, West Alabama 76 (OT) | Box score |
| 12/02/21 | Cleveland, MS | Delta State 54, Alabama Huntsville 52 | Box score |
| 11/22/21 | Cleveland, MS | Delta State 75, Arkansas-Monticello 66 | Box score |
| 11/20/21 | Dahlonega, GA | Clayton St. 56, Delta State 52 | Box score |
| 11/19/21 | Dahlonega, GA | North Georgia 67, Delta State 58 | Box score |
| 11/13/21 | Memphis, TN | Delta State 66, LeMoyne-Owen 57 | Box score |
| 11/12/21 | "Chappie" James Center Tuskegee, AL | Tuskegee University 69, Delta State 55 | Box score |